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Research

Overview

IBS CNM strives to develop breakthroughs in nanomedicine to gain a better understanding and control of nano-bio interface and the phenomena therein. We are developing nanomaterials and nanotools with unique functionality which can lead to new findings in biology and provide novel approaches in current medicine.

· Evolutionary Nanomaterials:
Nanomaterials we develop has the novel properties that differentiate nanomaterials from the bulk materials typically develop at a critical length scale of under 100 nm. The novel properties mentioned include unprecedented phenomena of optical, magnetic, electrical, and chemical properties which depends on the size and morphological scale factors. We develop designer nanomaterials which are intelligent and programmable such that they go through “self-evolution” process toward metastable state in terms of morphology and structure under certain stimuli with novel and optimized characteristics.

· Nano-bio Interface:
Nanomaterials at the biological interface have showcased their potential as a useful tool for mediating the physical world and biological systems. Nanomaterials can serve as versatile transducers that convert one physical quantity into another form of stimuli. For example, magnetic materials convert magnetic fields into mechanical force, heat, and light. Noble metals, quantum dots, and upconversion nanoparticles can transform light into heat or change the wavelength of the light. Beyond such versatility, biomolecule-conjugated nanomaterials can have distinct features, such as (I) remote controllability, (ii) spatiotemporal controllability, and (iii) molecular specificity, which provide opportunities to use nanoparticles as an attractive effector in biology and medicine. By adopting these characteristics of nanomaterials, we are studying possible ways of precise sensing or modulating various cellular behaviors and signaling pathways in order to provide new concepts and tools for diagnostics and therapeutics.

· Precision nanomedicine:
12Nanomedicine refers to design, synthesis, or application of nanomaterials for the basic understanding, diagnosis, and/or treatment of disease, being poised to revolutionize current health care. Many of the recent nanomaterial technologies show remarkable potential to provide new opportunities for innovation in medicine. We develop new concepts and optimized designs of nanomedicine and nanodevices to improve our fundamental understanding and to control biological systems in on-command and spatio-temporally regulated manner. By utilizing bio-machine interface at nanoscale, we are pursuing in precision nanomedicine, focused on cancer imaging and diagnosis, neuroscience, and genetic engineering.