작성일 : 2016.04.04 조회수 : 994
Thomson Reuters identified the most influential scientific minds of 2014 which was conducted by Web of Science and InCites. Prof. Cheon who has pioneered the field of nanoscience and nanomedicine with a number of breakthroughs in the “design of nanomaterials” and “new concepts of nano-imaging and therapeutics” received recognition for his highly cited research papers produced between 2002 and 2012. The publications of his work are found in journals such as Nature Materials, Nature Medicine, Nature Nanotechnology, Proceedings of the National Academy of Sciences, Accounts of Chemical Research, Journal of the American Chemical Society, and Angewandte Chemie and have received over 10,200 citations according to ISI Web of Science.
One of Prof. Cheon’s achievements is the establishment of mechanisms for shape guided synthesis of nanomaterials that serve as the guiding principles for the preparation of complex inorganic nanomaterials [JACS 2001, JACS 2002, Adv. Mater. 2003, Angew. Chem. 2006]. Based on these design concepts, Prof. Cheon has utilized nanomaterials as new and important tools for studying next-generation biomedical sciences. He demonstrated, for the first time, the nanoscale size-dependent magnetic resonance imaging (MRI) contrast effect which opened a new gateway to “nanomedicine” [JACS 2005]. Shortly after this discovery, Professor Cheon unveiled the world’s most advanced nano-MRI technology, MEIO (magnetism-engineered iron oxide) [Nature Medicine 2007], in which the as-developed nanoparticle agent displayed 10 times stronger MRI signals compared to those of conventional contrast agents. Additionally, he has developed multi-mode probes to enhance the imaging accuracy by designing opto-magnetic probe, PET-MRI probes, dual-mode T1-T2 MRI probes. Successful discrimination of true signal of biological targets could be attained by these developments, opening a new avenue for accurate diagnosis of disease.
In recent studies, he has focused on developing “nanoSwitch” that controls cell functions. He demonstrated that nanoparticles have the potential of becoming useful tools to control cell signaling pathways in a spatio-temporally regulated fashion. He developed “Magnetic nanoSwitch” to selectively regulate cellular fate such as programmed cell death (i.e., apoptosis) [Nature Materials 2012] and cell growth [Angew. Chem. 2010]. Another successful demonstration of nanomaterials for medicine is the invention of world best heat-emitting nanoparticle which can effectively lead to the cancer cell death by hyperthermia [Nature Nanotech. 2011]. These achievements have envisioned a new era of imaging and therapeutics for modern medicine catalyzed by nanoscience.